Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones.

Jae-Chul Jung, Soyong Jang, Yongnam Lee, Dongguk Min, Eunyoung Lim, Heyin Jung, Miyeon Oh, Seikwan Oh, Mankil Jung

Index: J. Med. Chem. 51 , 4054-8, (2008)

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Abstract

An efficient synthesis involving a key aldol reaction and biological properties of 1,3-diphenyl-2-propen-1-ones 8- 20 is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of 10 and 11 was 2 times higher than that for resveratrol. Compounds 9 and 11 were the strongest in suppression of in vitro nitric oxide (NO) generation and antiexcitotoxicity. Molecular modeling proposes an electron-donating group at the para position of acetophenones that leads to a dramatic increase in the suppression of NO production.