Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors

…, S Subramanian, GM Weerasekare…

Index: Zacheis, David; Dhar, Arindam; Lu, Shennan; Madler, Matora M.; Klucik, Jozef; Brown, Chad W.; Liu, Shengquan; Clement, Francis; Subramanian, Shankar; Mahika Weerasekare; Darrell Berlin; Gold, Michael A.; Houck Jr., John R.; Fountain, Kenneth R.; Benbrook, Doris M. Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4434 - 4445

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Citation Number: 43

Abstract

A class of less toxic retinoids, called heteroarotinoids, was evaluated for their molecular mechanism of growth inhibition of two head and neck squamous cell carcinoma (HNSCC) cell lines SCC-2 and SCC-38. A series of 14 heteroarotinoids were screened for growth inhibition activity in vitro. The two most active compounds, one that contained an oxygen heteroatom (6) and the other a sulfur heteroatom (16), were evaluated in a xenograph ...