Lipoic acid improves survival in transgenic mouse models of Huntington's disease.
O A Andreassen, R J Ferrante, A Dedeoglu, M F Beal
Index: Neuroreport 12(15) , 3371-3, (2001)
Full Text: HTML
Abstract
There is substantial evidence implicating excitotoxicity and oxidative damage in the pathogenesis of Huntington's disease (HD). We therefore examined whether the antioxidants 2-sulpho-tert-phenyibutyinitrone (S-PBN) and alpha-lipoic acid could exert neuroprotective effects in transgenic mouse models of HD. S-PBN showed no effects on either weight loss or survival in the R6/2 transgenic HD mice. alpha-Lipoic acid produced significant increases in survival in both R6/2 and N171-82Q transgenic mouse models of HD. These findings suggest that alpha-lipoic acid might have beneficial effects in HD patients.
Related Compounds
Related Articles:
Atypical effect of some spin trapping agents: reversible inhibition of acetylcholinesterase.
2000-02-15
[Free Radic. Biol. Med. 28(4) , 597-603, (2000)]
Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo.
1998-11-06
[Eur. J. Pharmacol. 360(2-3) , 155-63, (1998)]
Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059.
2001-04-01
[Free Radic. Res. 34(4) , 417-26, (2001)]
2012-01-01
[Xenotransplantation 19(3) , 166-76, (2012)]
2005-12-01
[Neurotoxicology 26(6) , 969-79, (2005)]