Cycloalkanones. 8. Hypocholesterolemic activity of long-chain ketones related to pentadecanone.
S D Wyrick, I H Hall, C Piantadosi, C R Fenske
Index: J. Med. Chem. 19(2) , 219-22, (1976)
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Abstract
Aliphatic analogs of 2,8-dibenzylcyclooctanone which includes C15-C18 ketones have been investigated for hypocholesterolemic activity in rats. The position of the carbonyl group in the chain for maximum activity appears to be the 2 position. 2-Hexadecanone reduced serum cholesterol levels significantly without altering serum triglyceride levels. This drug was not estrogenic at effective doses which is in contrast to the cyclooctanones which possess this activity.
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