UKEMS genotoxicity trial 1981. In vivo assay systems.

J C Topham

Index: Mutat. Res. 100(1-4) , 381-7, (1982)

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Abstract

4CMB was tested in 7 mouse micronucleus assays (3 i.p., 2 oral, 1 s.c., 1 foetal), 2 mouse sperm-head morphology assays (1 i.p., 1 s.c.), 1 dominant lethal test in mouse (oral), 3 SLRL tests in Drosophila (2 feeding, 1 injection) and one somatic cell segregation assay in Drosophila (feeding). 4HMB was tested in 4 mouse micronucleus assays (2 i.p., 1 oral, 1 s.c.), 2 mouse sperm morphology assays (1 i.p. and 1 s.c.). 1 SLRL test and 1 somatic cell segregation assay in Drosophila (both feeding). BC was tested in 4 mouse micronucleus assays (2 i.p., 2 oral, 1 s.c.), 2 sperm-morphology assays (1 i.p., 1 s.c.), 2 SLRL tests and 1 somatic cell segregation assay in Drosophila (all feeding). All the mouse assays gave negative results with all 3 compounds. The response of 4CMB and BC was not reproducible when tested under similar conditions in the SLRL test in Drosophila. All 3 compounds gave a positive response in the somatic cell segregation assay in Drosophila.