4-(Chloromethyl)biphenyl

Names

[ Name ]:
4-(Chloromethyl)biphenyl

[Synonym ]:
4-(Chloromethyl)-1,1'-biphenyl
4-(Chloromethyl)biphenyl
1-(chloromethyl)-4-phenylbenzene
1,1'-Biphenyl, 4-(chloromethyl)-
EINECS 216-786-5
Biphenyl, 4- (chloromethyl)-
MFCD00000917

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
322.4±21.0 °C at 760 mmHg

[ Melting Point ]:
70-73 °C(lit.)

[ Molecular Formula ]:
C₁₃H₁₁Cl

[ Molecular Weight ]:
202.679

[ Flash Point ]:
143.2±14.7 °C

[ Exact Mass ]:
202.054932

[ LogP ]:
4.24

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.579

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV2087000

CHEMICAL NAME :: Biphenyl, 4-(chloromethyl)-

CAS REGISTRY NUMBER :: 1667-11-4

BEILSTEIN REFERENCE NO. :: 1863327

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C13-H11-Cl

MOLECULAR WEIGHT :: 202.69

WISWESSER LINE NOTATION :: G1R DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 250 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2500 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Kidney

DOSE/DURATION :: 2500 ug/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 2,33,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DV2087000

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

The biological activity of 4-chloromethylbiphenyl, benzyl chloride and 4-hydroxymethylbiphenyl in 4 short-term tests for carcinogenicity. A report of an individual study in the UKEMS genotoxicity trial 1981.

Mutat. Res. 119(2) , 121-33, (1983)

4-Chloromethylbiphenyl (4CMB), benzyl chloride (BC) and 4-hydroxymethyl-biphenyl (4HMB) were tested for biological activity in the following assays: (i) the Salmonella/microsome assay; (ii) a bacteria...

The use of cultured mammalian cells the UKEMS collaborative genotoxicity trial (1981).

Mutat. Res. 100(1-4) , 271-6, (1982)

The effects of 4CMB, 4HMB and BC in the micronucleus test.

Mutat. Res. 100(1-4) , 353-6, (1982)