Nucleic Acids Symposium Series 2000-01-01

Introduction of a benzoyl group onto 6-chloropurine riboside in aqueous solution and its application to the synthesis of nucleoside derivatives.

T Maruyama, S Kozai, S Takamatsu, K Izawa

Index: Nucleic Acids Symp. Ser. 44 , 103-104, (2000)

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Abstract

A benzoyl group was introduced onto the 3'-hydroxyl group of 6-chloropurine riboside by treatment with benzoic anhydride in the presence of a base in aqueous solution. The product (3b) was converted to 9-(2,3-Di-deoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine (1, FddA) in 6 steps, including radical deoxygenation.

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