Solid phase synthesis of functionalized biaryl ethers: versatile scaffolds for combinatorial chemistry.
J C Wijkmans, A J Culshaw, A D Baxter
Index: Mol. Divers. 3(2) , 117-20, (1997)
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Abstract
4-Fluoro-3-nitrobenzoic acid attached to a solid support was shown to react under mild conditions with a wide range of functionalized phenols to yield, after cleavage, the corresponding biaryl ethers in excellent purity. In a similar fashion, biaryl thioethers could be obtained. Further elaboration of immobilized biaryl ethers demonstrates the potential for combinatorial library generation.
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