Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART.

Karin K Pedersen, Ingjerd W Manner, Ingebjørg Seljeflot, Dag Kvale, Ingrid Os, Jan Gerstoft, Susanne D Nielsen, Marius Trøseid

Index: J. Acquir. Immune Defic. Syndr. 67(4) , 370-4, (2014)

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Abstract

Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.