Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity.

In-Kyoung Lee, Bong-Sik Yun

Index: Bioorg. Med. Chem. Lett. 16 , 2376-9, (2006)

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Abstract

Three new free radical scavengers were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compound davallialactone. Their structures were established as hispidin analogs by extensive NMR spectral data. Compounds 3 and 4 displayed significant scavenging activity against the superoxide radical anion, ABTS radical cation, and DPPH radical, while 1 and 2 exhibited potent antioxidative activity only against ABTS radical cation.