Chemoselective and regiospecific Suzuki coupling on a multisubstituted sp(3)-carbon in 1,1-diborylalkanes at room temperature.
Kohei Endo, Takahiro Ohkubo, Munenao Hirokami, Takanori Shibata
Index: J. Am. Chem. Soc. 132 , 11033, (2010)
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Abstract
The palladium-catalyzed Suzuki-Miyaura cross-coupling on a multisubstituted sp(3)-carbon in 1,1-diborylalkanes was achieved at room temperature. The generation of a monoborate intermediate by virtue of the adjacent B atom could result in the chemoselective coupling reaction under ambient conditions.
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