Novel reductive Friedel-Crafts alkylation of aromatics catalyzed by indium compounds: Chemoselective utilization of carbonyl moieties as alkylating reagents

T Miyai, Y Onishi, A Baba

Index: Miyai, Takashi; Onishi, Yoshiyuki; Baba, Akio Tetrahedron, 1999 , vol. 55, # 4 p. 1017 - 1026

Full Text: HTML

Citation Number: 72

Abstract

Reductive Friedel-Crafts alkylation of aromatics with ketones or aldehydes was characteristically catalyzed by indium compounds in preference to general catalysts like AlCl3 and BF3, where hydrosilanes would play an important role both as a hydride donor and as a co-catalyst. Chemoselective utilization of ketone moieties as alkylating reagents took place even in the presence of halogen, ester or ether moieties which are very ...