Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects
GS Hamilton, YQ Wu, DC Limburg…
Index: Journal of Medicinal Chemistry, , vol. 45, # 16 p. 3549 - 3557
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Citation Number: 38
Abstract
... Journal of Medicinal Chemistry. ... Chemistry. Scheme 1 shows the general synthetic route for the compounds. Reaction of proline methyl ester or methyl pipecolinate with methyl chlorooxoacetate provided the oxamate as the key intermediate. ...
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