Use of dimethyl carbonate as a solvent greatly enhances the biaryl coupling of aryl iodides and organoboron reagents without adding any transition metal catalysts.

Kiyofumi Inamoto, Chisa Hasegawa, Kou Hiroya, Yoshinori Kondo, Takao Osako, Yasuhiro Uozumi, Takayuki Doi

Index: Chem. Commun. (Camb.) 23th ed., 48 , 2912-2914, (2012)

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Abstract

The coupling reaction of aryl iodides with arylboronic acids to give biaryl compounds can be efficiently performed without adding a transition metal catalyst. The key to success is the use of dimethyl carbonate as a solvent. This finding provides a new strategy for constructing a biaryl linkage.