Evidence for SN 2 (P) mechanism in the phosphorylation of alkaline phosphatase by substrates
A Williams, RA Naylor
Index: Williams,A.; Naylor,R.A. Journal of the Chemical Society [Section] B: Physical Organic, 1971 , p. 1973 - 1979
Full Text: HTML
Citation Number: 27
Abstract
Michaelis–Menten parameters have been measured for a series of alkyl-, aryl-, and arylamido-phosphates as substrates of alkaline phosphatase. Kinetic parameters for p- bromophenylamido-phosphate were measured over a pH-range and the results, including inhibition by inorganic phosphate indicated the amides to be normal substrates of the enzyme. Little variation in the parameter k0 was observed for all substrates; the parameter ...
Related Articles:
An improved synthesis of monoesters of phosphoric acid
[Modro, Agnes M.; Modro, Tomasz A. Organic Preparations and Procedures International, 1992 , vol. 24, # 1 p. 57 - 60]
Oxidative Cleavage of o??Hydroxyphenyl Phosphate by Iodobenzene Diacetate
[Wu, Pei-Lin; Chen, Jhy-Hong; Huang, Ded-Shih Journal of the Chinese Chemical Society, 1999 , vol. 46, # 6 p. 967 - 970]
[Quintana, Jose Benito; Rodil, Rosario; Reemtsma, Thorsten Analytical Chemistry, 2006 , vol. 78, # 5 p. 1644 - 1650]
[Finnegan,R.A.; Matson,J.A. Journal of the Chemical Society, Chemical Communications, 1975 , p. 928 - 929]
[Virag, Tamas; Elrod, Don B.; Liliom, Karoly; Sardar, Vineet M.; Parrill, Abby L.; Yokoyama, Kazuaki; Durgam, Gangadhar; Deng, Wenlin; Miller, Duane D.; Tigyi, Gabor Molecular Pharmacology, 2003 , vol. 63, # 5 p. 1032 - 1042]