Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors

…, VM Sardar, AL Parrill, K Yokoyama, G Durgam…

Index: Virag, Tamas; Elrod, Don B.; Liliom, Karoly; Sardar, Vineet M.; Parrill, Abby L.; Yokoyama, Kazuaki; Durgam, Gangadhar; Deng, Wenlin; Miller, Duane D.; Tigyi, Gabor Molecular Pharmacology, 2003 , vol. 63, # 5 p. 1032 - 1042

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Citation Number: 72

Abstract

Abstract A more complete understanding of the physiological and pathological role of lysophosphatidic acid (LPA) requires receptor subtype-specific agonists and antagonists. Here, we report the synthesis and pharmacological characterization of fatty alcohol phosphates (FAP) containing saturated hydrocarbon chains from 4 to 22 carbons in length. Selection of FAP as the lead structure was based on computational modeling as a minimal ...