Aqua [1-(2, 6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine](sulfato) platinum (II) complexes with variable substituents in the 2-phenyl ring. 1. Synthesis and …

R Gust, T Burgemeister, A Mannschreck…

Index: Gust, Ronald; Burgemeister, Thomas; Mannschreck, Albrecht; Schoenenberger, Helmut Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2535 - 2544

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Citation Number: 63

Abstract

Erythro-and threo-configurated aqua [l-(2, 6-dichloro-4-hydroxyphenyl)-2-phenylethylen~ i~~ e](sulfato) platinum (II) complexes with variable substituents in the 2-phenyl ring (2-PtSO, to 9-PtS0,: H, 4-F, 3-OH, 4-OH, 2, 6-Fz, 2, 6-Clz, 2-F/4-OH, 2-C1/4-OH) were synthesized and tested for estrogenic and antitumor activities. The ligands were obtained by a three-step reaction. The stilbenes were reacted with a mixture of IN3 and NaN3 to yield the ...