Asymmetric synthesis of fluorinated L-tyrosine and meta-L-tyrosines
M Monclus, C Masson, A Luxen
Index: Monclus, Michel; Masson, Carine; Luxen, Andre Journal of Fluorine Chemistry, 1995 , vol. 70, # 1 p. 39 - 44
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Citation Number: 10
Abstract
A convenient asymmetric synthesis of (2S)-2-amino-3-(2-fluoro-5-hydroxyphenyl) propanoic acid,(2S)-2-amino-3-(4-fluoro-3-hydroxyphenyl) propanoic acid and (2S)-2-amino-3-(2- fluoro-4-hydroxyphenyl) propanoic acid is described. Key steps include the synthesis of the benzyl bromides, the alkylation of the glycine enolate derivative ((S)-Boc-BMI) and the hydrolysis of the alkylated Boc-BMI.
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Asymmetric synthesis of fluorinated L-tyrosine and meta-L-tyrosines
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