2-, 3-, and 4-(. alpha.,. alpha.,. beta.,. beta.-Tetrafluorophenethyl) benzylamines. A new class of antiarrhythmic agents
…, JB Wong, EL Engelhardt, ML Torchiana…
Index: Christy; Colton; Mackay; Staas; Wong; Engelhardt; Torchiana; Stone Journal of Medicinal Chemistry, 1977 , vol. 20, # 3 p. 421 - 430
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Citation Number: 13
Abstract
28 also was obtained from the acid 20 via the Curtius reaction and hydrolysis of the urethane 25 to the aniline 26. Preparation of a bis (benzy1amine) derivative in the ortho- substituted series from the 2, 2'-dibromide 2i failed when 2i proved to be resistant to reaction with CuCN. Alternatively, the 2, 2'-dimethyl compound 2g was dibrominated successfully with NBS and the bis (benzy1 bromide) 27 underwent the Delepine reaction to afford the ...
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