Journal of Medicinal Chemistry 1989-05-01

Synthesis and dopaminergic activity of 2-substituted octahydrobenzo[f]quinolines.

J C Craig, S M Torkelson, P R Findell, R I Weiner

Index: J. Med. Chem. 32 , 961, (1989)

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Abstract

A series of 2-substituted octahydrobenzo[f]quinolines has been synthesized and assayed for dopamine agonist activity. Only the compounds corresponding to the beta-rotameric conformation of dopamine showed biphasic activity in competition binding studies with the radioligand [3H]spiroperidol. These findings suggest that the congeners possessing the beta-rotamer conformation show receptor-binding characteristics that resemble those of the ergolines more closely than do those of the corresponding alpha-rotamer congeners.