Determination of preservatives in cosmetics, cleaning agents and pharmaceuticals using fast liquid chromatography.
Irena Baranowska, Iwona Wojciechowska, Natalia Solarz, Ewa Krutysza
Index: J. Chromatogr. Sci. 52(1) , 88-94, (2013)
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Abstract
This paper reports the development of a method for simultaneously determining five preservatives in cosmetics, cleaning agents and pharmaceuticals by fast liquid chromatography. Methylisothiazolinone, methylchloroisothiazolinone, benzyl alcohol, sodium benzoate and methylparaben were separated on a Chromolith Fast Gradient reversed-phase 18e column using gradient elution with acetonitrile and a 0.1% aqueous solution of formic acid, with a run time of 3 min. The preparation of solid and liquid samples included ultrasonic extraction with methanol with recoveries ranging from 69 to 119%. The developed method was used to analyze samples of cosmetics (66 samples), cleaning agents (five samples) and pharmaceutical industry products (17 samples).
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