Persistent developmental toxicity in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides.

Pernille Rosenskjold Jacobsen, Marta Axelstad, Julie Boberg, Louise Krag Isling, Sofie Christiansen, Karen Riiber Mandrup, Line Olrik Berthelsen, Anne Marie Vinggaard, Ulla Hass

Index: Reprod. Toxicol. 34(2) , 237-50, (2012)

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Abstract

There is growing concern of permanent damage to the endocrine and nervous systems after developmental exposure to endocrine disrupting chemicals. In this study the permanent reproductive and neurobehavioral effects of combined exposure to five endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, were examined. Pregnant and lactating rat dams were dosed with a mixture of the five pesticides at three different doses, or with the individual pesticides at one of two doses. Adverse effects were observed in young and adult male offspring from the group exposed to the highest dose of the mixture. These included reduced prostate and epididymis weights, increased testes weights, altered prostate histopathology, increased density of mammary glands, reduced sperm counts, and decreased spatial learning. As no significant effects were seen following single compound exposure at the doses included in the highest mixture dose, these results indicate cumulative adverse effects of the pesticide mixture.Copyright © 2012 Elsevier Inc. All rights reserved.