Gi-protein inhibitor, guanosine 5′-O-(2-thiodiphosphate), induces senescence-associated β-galactosidase positive cell formation through CREB phosphorylation

E.Y. Moon, H.S. Kim, Y.S. Im, E.Y. Moon, H.S. Kim, Y.S. Im

Index: Leuk. Res. 86 , 683-90, (2010)

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Abstract

Aims We evaluated Gi-protein inhibitor, guanosine 5′-O-(2-thiodiphosphate)(GOT)-induced senescence-associated(SA)-β-galactosidase(Gal) positive cell formation to determine if it occurred through phosphorylation of cyclic AMP-dependent response element binding protein (CREB).