Topical treatment of hyperpigmentation disorders.

M Rendon, S Horwitz

Index: Ann. Dermatol. Venereol. 139 Suppl 4 , S153-8, (2012)

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Abstract

Hyperpigmentation has traditionally been a relatively difficult condition to treat, especially in darker racial ethnic groups. Multiple topical agents available act upon different steps of the pigmentation pathway. We review these topical agents, their mechanisms of action, and their effectiveness as monotherapy and in combination with other compounds. Ultimately, combination therapy is the most efficacious when considering overall depigmentation as well as treatment time required to achieve clinical improvement.Copyright © 2012 Elsevier Masson SAS. All rights reserved.