Differential acute toxicity of tetrachlorobenzene isomers to oligochaetes in soil and water: application of the critical body residue concept.

Christopher M Hurdzan, Roman P Lanno, David M Sovic

Index: Bull. Environ. Contam. Toxicol. 87(3) , 209-14, (2011)

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Abstract

The acute, lethal potency of the 1,2,3,4-, 1,2,4,5- and 1,2,3,5-tetrachlorobenzene isomers was compared in the terrestrial and aquatic oligochaetes Eisenia andrei and Tubifex tubifex. 1,2,4,5-TeCB was neither lethal, nor produced any perceptible adverse effects, at lipid normalized concentrations predicted to be lethal according to the well-established critical body residue concept. If a narcotic is defined as a substance capable of inducing narcosis, rather than a substance displaying certain physical or chemical properties (e.g., log K(ow)), then we do not believe these findings challenge the critical body residue because by the former definition, 1,2,4,5-tetrachlorobenzene is not a narcotic.