Phytochemistry 2010-01-01

Three nicotine demethylase genes mediate nornicotine biosynthesis inNicotiana tabacumL.: Functional characterization of theCYP82E10gene

Ramsey S. Lewis, Steven W. Bowen, Matthew R. Keogh, Ralph E. Dewey, Ramsey S. Lewis, Steven W. Bowen, Matthew R. Keogh, Ralph E. Dewey, Ramsey S. Lewis, Steven W. Bowen, Matthew R. Keogh, Ralph E. Dewey

Index: Phytochemistry 71(17-18) , 1988-98, (2010)

Full Text: HTML

Abstract

Nornicotine is a nicotine metabolite that serves as a precursor in the formation of N′-nitrosonornicotine, a compound shown to be carcinogenic in numerous animal studies. Knocking out the function of all known tobacco N-demethylase genes through targeted mutagenesis is an effective strategy for minimizing the nornicotine content of tobacco.

Related Compounds

Related Articles:

6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.

2005-02-15

[Bioorg. Med. Chem. Lett. 15 , 877-81, (2005)]

3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands.

2005-10-01

[Bioorg. Med. Chem. Lett. 15 , 4308-12, (2005)]

Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine.

2013-03-01

[Nicotine Tob. Res. 15(3) , 622-32, (2013)]

The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.

2010-01-01

[Pharmacol. Biochem. Behav. 94(3) , 352-62, (2010)]

A novel pathway for nicotine degradation by Aspergillus oryzae 112822 isolated from tobacco leaves.

2010-09-01

[Res. Microbiol. 161(7) , 626-33, (2010)]

More Articles...