Organic & Biomolecular Chemistry 2008-08-07

The tert-butyl group in chemistry and biology.

Philippe Bisel, Loay Al-Momani, Michael Müller

Index: Org. Biomol. Chem. 6(15) , 2655-65, (2008)

Full Text: HTML

Abstract

The unique reactivity pattern elicited by the crowded tert-butyl group is highlighted by summarising characteristic applications. Starting from the use of this simple hydrocarbon moiety in chemical transformations, via its relevance in Nature and its implication in biosynthetic and biodegradation pathways, the way through to its possible application in biocatalytic processes is described.


Related Compounds

Related Articles:

Highly selective asymmetric acetate aldol reactions of an N-acetyl thiazolidinethione reagent.

2004-01-08

[Org. Lett. 6 , 23-25, (2004)]

Scaleable catalytic asymmetric Strecker syntheses of unnatural alpha-amino acids.

2009-10-15

[Nature 461(7266) , 968-70, (2009)]

An efficient and selective enzymatic oxidation system for the synthesis of enantiomerically pure D-tert-leucine.

2003-10-02

[Org. Lett. 5(20) , 3649-50, (2003)]

Effect of organic cosolvent on kinetic resolution of tert-leucine by penicillin G acylase from Kluyvera citrophila.

2006-04-01

[Bioprocess Biosyst. Eng. 28(5) , 285-9, (2006)]

Preferred conformations of peptides containing tert-leucine, a sterically demanding, lipophilic alpha-amino acid with a quaternary side-chain Cbeta atom.

2005-04-08

[Chemistry 11(8) , 2395-404, (2005)]

More Articles...