Nucleosides, Nucleotides & Nucleic Acids 2001-12-01

Synthesis of carbocyclic orotidine analogs as potential orotidine decarboxylase inhibitors.

G Y Song, F N Naguib, M H el Kouni, C K Chu

Index: Nucleosides Nucleotides Nucleic Acids 20(12) , 1915-25, (2001)

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Abstract

An asymmetric synthesis of carbocyclic orotidine 15 and its monophosphate 16 were accomplished via the key intermediate cyclopentanone 4, which was prepared from D-gamma-ribonolactone in steps. None of synthesized the compounds inhibited orotidine 5'-monophosphate decarboxylase (EC 4.1.1.23) or orotate phosphoribosyltransferase (EC 2.4.2.10).

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