Ceric ammonium nitrate (CAN) mediated esterification of N-Boc amino acids allows either retention or removal of the N-Boc group
A Kuttan, S Nowshudin, MNA Rao
Index: Kuttan, Ashani; Nowshudin, Shiek; Rao Tetrahedron Letters, 2004 , vol. 45, # 12 p. 2663 - 2665
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Citation Number: 18
Abstract
Reaction of N-Boc amino acids with ceric ammonium nitrate in an alcohol as the solvent at room temperature resulted in the esterification of N-Boc amino acids with Boc group retention. When the reaction was conducted at reflux temperature, esterification was accompanied with simultaneous removal of the Boc group. Both reactions gave the desired products in good yields.
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