A one-step synthesis of pseudoephedrine glycinamide, a versatile precursor for the synthesis of α-amino acids
AG Myers, T Yoon, JL Gleason
Index: Myers, Andrew G.; Yoon, Taeyoung; Gleason, James L. Tetrahedron Letters, 1995 , vol. 36, # 26 p. 4555 - 4558
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Citation Number: 39
Abstract
Both enantiomers of pseudoephedrine glycinamide [(+)-or (−)-1] were synthesized by either of two procedures:(1) a standard two-step coupling of N-Boc-Gly with pseudoephedrine followed by deprotection, or (2) a more economical one-step coupling reaction of Gly-OMe with pseudoephedrine mediated by LiCl and base.
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