Conversion of a (sp 3) C–F bond of alkyl fluorides to (sp 3) C–X (X= Cl, C, H, O, S, Se, Te, N) bonds using organoaluminium reagents

…, SA Begum, Y Shinohara, M Tomita, Y Naitoh…

Index: Terao, Jun; Begum, Shameem Ara; Shinohara, Yoshiaki; Tomita, Masahiro; Naitoh, Yoshitaka; Kambe, Nobuaki Chemical Communications, 2007 , # 8 p. 855 - 857

Full Text: HTML

Citation Number: 35

Abstract

Organic fluorides, especially those having an (sp 3 )C–F bond, have been recognized as the most inert class of organic compounds due to the strong C–F bonds. Hence, to develop reactions which replace fluorine atoms with other atoms or groups is a challenging subject in organic chemistry. 1,2 It is known that (sp 3 )C–F bonds would be cleaved when treated with a strong hard acid in polar solvent and/or at elevated temperatures. Organoaluminium reagents or ...

Related Articles:

Selective N-alkylation of amines using nitriles under hydrogenation conditions: facile synthesis of secondary and tertiary amines

[Ikawa, Takashi; Fujita, Yuki; Mizusaki, Tomoteru; Betsuin, Sae; Takamatsu, Haruki; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao Organic and Biomolecular Chemistry, 2012 , vol. 10, # 2 p. 293 - 304]

Vinyl-copper derivatives XII: Stereospecific synthesis of allylic amines by aminomethylation of organocopper reagents

[Germon, C.; Alexakis, A.; Normant, J. F. Tetrahedron Letters, 1980 , vol. 21, p. 3763 - 3766]

Cytostatica

[Westphal; Jerchel Chemische Berichte, 1940 , vol. 73, p. 1007]

The Hydrogenation of Amides and Ammonium Salts. The Transalkylation of Tertiary Amines

[Schneider et al. Journal of the American Chemical Society, 1952 , vol. 74, p. 4287,4288]

The Hydrogenation of Amides and Ammonium Salts. The Transalkylation of Tertiary Amines

[Schneider et al. Journal of the American Chemical Society, 1952 , vol. 74, p. 4287,4288]

More Articles...