SnO(2)-ZnSn(OH)(6): a novel binary affinity probe for global phosphopeptide detection.

Li-Ping Li, Tao Zheng, Lin-Nan Xu, Ze Li, Ling-Dong Sun, Zong-Xiu Nie, Yu Bai, Hu-Wei Liu

Index: Chem. Commun. (Camb.) 49(17) , 1762-4, (2013)

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Abstract

ZnSn(OH)(6) and binary-component SnO(2)-ZnSn(OH)(6) were introduced as affinity probes for phosphopeptide enrichment for the first time. Two strategies, either ZnSn(OH)(6) and SnO(2) serial enrichment or binary-component SnO(2)-ZnSn(OH)(6) enrichment in a single run, were proposed to enhance multi-phosphopeptide enrichment and to significantly improve global phosphopeptide detection.