Synthesis of α??Amino Acid Amides: Ruthenium??Catalyzed Amination of α??Hydroxy Amides

M Zhang, S Imm, S Bähn, H Neumann…

Index: Zhang, Min; Imm, Sebastian; Baehn, Sebastian; Neumann, Helfried; Beller, Matthias Angewandte Chemie - International Edition, 2011 , vol. 50, # 47 p. 11197 - 11201

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Citation Number: 71

Abstract

Dedicated to Professor Christian Bruneau on the occasion of his 60th birthday α-Amino acid amides represent an interesting subclass of amino acid derivatives. In general, such compounds are biologically active and possess therapeutically useful properties. Selected examples of such compounds are: 1, which is used for the treatment of metabolic syndrome,[1] potent inhibitors for 11-β-hydroxysteroid dehydrogenase 1 (2),[2] and top- ...