2-Aminopyrimidine as a novel scaffold for biofilm modulation.

Erick A Lindsey, Roberta J Worthington, Cristina Alcaraz, Christian Melander

Index: Org. Biomol. Chem. 10(13) , 2552-61, (2012)

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Abstract

An efficient synthetic route to a series of substituted 2-aminopyrimidine (2-AP) derivatives has been developed. Subsequent biofilm screening has allowed comparison between the biological activity of these new derivatives and that of the 2-aminoimidazole class of anti-biofilm compounds. Several derivatives displayed the ability to modulate bacterial biofilm formation, exhibiting greater activity against Gram-positive strains than Gram-negative strains. Additionally some 2-aminopyrmidines were able to suppress MRSA resistance to conventional antibiotics.