Reductive cleavage of t-butyldimethylsilyl ethers with sodium hydride

MS Shekhani, KM Khan, K Mahmood

Index: Shekhani, Mohammed Saleh; Khan, Mohammed Khalid; Mahmood, Khalid Tetrahedron Letters, 1988 , vol. 29, # 47 p. 6161 - 6162

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Citation Number: 25

Abstract

In a typical experiment, to a well stirred suspension of NaH in HMPA, under argon, was added dropwise a solution of the silyl ether in HMPA (in cases where the silyl ether is not soluble in HMPA a saturated solution in THF can be added), and the mixture was allowed to stir at 25OC. In general 2 equiv. of NaH were used per equiv. of the silyl ether (additional NaH was used to account for the free hydroxyl groups wherever necessary). ... 1,2,4,6, and ll), were ...