ACS medicinal chemistry letters

Preparative microfluidic electrosynthesis of drug metabolites

R Stalder, GP Roth

Index: Stalder, Romain; Roth, Gregory P. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 11 p. 1119 - 1123

Full Text: HTML

Citation Number: 28

Abstract

In vivo, a drug molecule undergoes its first chemical transformation within the liver via CYP450-catalyzed oxidation. The chemical outcome of the first pass hepatic oxidation is key information to any drug development process. Electrochemistry can be used to simulate ...

Related Articles:

The chemistry of aryllead (IV) tricarboxylates. Reaction with derivatives of malonic acid: New routes to α-aryl carboxylic acids and arylated barbituric acid derivatives

[Kopinski, Richard P.; Pinhey, John T.; Rowe, Bruce A. Australian Journal of Chemistry, 1984 , vol. 37, # 6 p. 1245 - 1254]

New chemical aspects of primidone metabolism

[Lafont; Cave; Menager; Miocque European Journal of Medicinal Chemistry, 1990 , vol. 25, # 1 p. 61 - 66]

Butanones: Monoketones

[Arai; Tamura; Kawai; Nakajima Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 3117 - 3118]

More Articles...