New chemical aspects of primidone metabolism
O Lafont, C Cavé, S Ménager, M Miocque
Index: Lafont; Cave; Menager; Miocque European Journal of Medicinal Chemistry, 1990 , vol. 25, # 1 p. 61 - 66
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Citation Number: 7
Abstract
Abstract Primidone is metabolized either into phenylethylmalondiamide or phenobarbital. 2- Hydroxyprimidone was synthesized and tested as a potential intermediate common to these two biodegradation pathways in dogs as well as in vitro. On the other hand, the mechanism of the formation of α-phenyl-γ-butyrolactone during intoxication was investigated and the role of precursor played by the phenobarbital generated in vivo was shown.
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