Application of the equivalency factor concept to the phototoxicity and –genotoxicity of furocoumarin mixtures

Nicole Raquet, Dieter Schrenk

Index: Food Chem. Toxicol. 68 , 257-66, (2014)

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Abstract

• The photo-cytotoxic, -mutagenic, and -clastogenic properties in V79 cells of thirteen furocoumarins (FCs), were analyzed. • Nine FC mixtures including one mixture ‘representing’ FCs in Angelica archangelica extract were tested. • The concept of relative potency factors for photo-cytotoxicity, -mutagenicity, and -clastogenicity was applicable to all congeners. • The concept was applied successfully to binary mixtures of 5- and 8-methoxypsoralen and to complex FC mixtures.