Nicotinamide adenine dinucleotide: beyond a redox coenzyme.
Hening Lin
Index: Org. Biomol. Chem. 5 , 2541-2554, (2007)
Full Text: HTML
Abstract
ADP-ribosylation using nicotinamide adenine dinucleotide (NAD+) is an important type of enzymatic reaction that affects many biological processes. A brief introductory review is given here to various ADP-ribosyltransferases, including poly(ADP-ribose) polymerase (PARPs), mono(ADP-ribosyl)-transferases (ARTs), NAD(+)-dependent deacetylases (sirtuins), tRNA 2'-phosphotransferases, and ADP-ribosyl cyclases (CD38 and CD157). Focus is given to the enzymatic reactions, mechanisms, structures, and biological functions.
Related Compounds
Related Articles:
Are retinoids potential therapeutic agents in disorders of social cognition including autism?
2011-06-06
[FEBS Lett. 585 , 1529-1536, (2011)]
ADP-ribosylation of histones by ARTD1: An additional module of the histone code?
2011-06-06
[FEBS Lett. 585 , 1595-1599, (2011)]
Mammalian sirtuins and energy metabolism.
2011-01-01
[Int. J. Biol. Sci. 7 , 575-587, (2011)]
NAD+ and NADH in cellular functions and cell death.
2006-01-01
[Front. Biosci. 11 , 3129-3148, (2006)]
"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging.
2010-08-01
[Biochim. Biophys. Acta 1804 , 1584-1590, (2010)]