Activity of inosine analogs against Pneumocystis carinii in culture.

M S Bartlett, J J Marr, S F Queener, R S Klein, J W Smith

Index: Antimicrob. Agents Chemother. 30(1) , 181-3, (1986)

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Abstract

Three analogs of inosine, formycin B, allopurinol ribonucleoside, and 9-deazainosine, were tested for their ability to suppress proliferation of Pneumocystis carinii in culture with WI-38 cells. The organism was inhibited by 9-deazainosine at 10 micrograms/ml, and there was some inhibition at 1 microgram/ml. Formycin B was effective only at 40 micrograms/ml. Allopurinol ribonucleoside had little effect.