Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase
Y Yamano, K Tsuboi, Y Hozaki, K Takahashi…
Index: Yamano, Yumiko; Tsuboi, Kazuhito; Hozaki, Yuki; Takahashi, Kiyohiro; Jin, Xing-Hua; Ueda, Natsuo; Wada, Akimori Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 11 p. 3658 - 3665
Full Text: HTML
Citation Number: 23
Abstract
N-Acylethanolamines (NAEs) including N-arachidonoylethanolamine (anandamide) and N- palmitoylethanolamine are endogenous lipid mediators. These molecules are degraded to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH) or NAE-hydrolyzing acid amidase (NAAA). Lipophilic amines, especially pentadecylamine (2c) and tridecyl 2-aminoacetate (11b), were found to exhibit potent NAAA inhibitory activities ( ...
Related Articles:
Analogs of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone
[Wissner, A.; Schaub, R. E.; Sum, P.-E.; Kohler, C. A.; Goldstein, B. M. Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1181 - 1187]
Higher alkyl monoethers of mono-to tetraethylene glycol2a, b
[Wrigley,A.N. et al. Journal of Organic Chemistry, 1960 , vol. 25, p. 439 - 444]