Mix-and-heat benzylation of alcohols using a bench-stable pyridinium salt.

Kevin W C Poon, Gregory B Dudley

Index: J. Org. Chem. 71 , 3923, (2006)

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Abstract

2-Benzyloxy-1-methylpyridinium triflate (1) is a stable, neutral organic salt that converts alcohols into benzyl ethers upon warming. The synthesis and reactivity of 1 are described herein. Benzylation of a wide range of alcohols occurs in good to excellent yield.