Brazilian Journal of Medical and Biological Research 1988-01-01

Circadian stage-dependent effect of ACTH and melatonin on protein synthesis by rat adrenal cells.

N Marques, S Sánchez de la Peña, F Ungar, F Halberg

Index: Braz. J. Med. Biol. Res. 21(4) , 759-62, (1988)

Full Text: HTML

Abstract

The objective of the present study was to determine the circadian effects of melatonin and two different ACTH preparations: a synthetic heptadecapeptide with adrenocorticotrophic action (Synchrodyn 1-17, HOE 433) and a natural ACTH (Acthar, Armour). Both ACTH preparations acted in a circadian stage-dependent fashion affecting the MESOR and the amplitude of total protein synthesis of rat adrenal cells. The results also indicated interaction of melatonin with the rhythmic action of ACTH. We conclude that circadian adrenocortical organization also modulates protein synthesis.

Related Compounds

Related Articles:

Differences in cortisol, aldosterone and testosterone responses to ACTH 1-17 administered at two different times of day.

1987-01-01

[Chronobiologia 14(1) , 39-46, (1987)]

Acute and chronic effects of human recombinant GH (hrGH) on adrenal steroidogenesis in children affected with isolated GH deficiency (IGHD).

1995-07-01

[J. Clin. Endocrinol. Metab. 80(7) , 2251-4, (1995)]

N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia.

1988-08-01

[Acta Neurol. Scand 78(2) , 146-51, (1988)]

Dopaminergic regulation of aldosterone secretion: assessment in different subtypes of primary aldosteronism and in essential hypertension.

1991-01-01

[J. Int. Med. Res. 19(1) , 44-9, (1991)]

Dysregulation of adrenal 11 beta-hydroxylase activity in hypertensive subjects: usefulness of the ACTH 1-17 stimulation test.

1999-08-01

[Nutr. Metab. Cardiovasc. Dis. 9(4) , 192-5, (1999)]

More Articles...