N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia.

G Nappi, F Facchinetti, E Martignoni, F Petraglia, E Sinforiani, G Bono, A R Genazzani

Index: Acta Neurol. Scand 78(2) , 146-51, (1988)

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Abstract

Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with beta-EP activities in CNS is discussed.