Drug Metabolism and Disposition 1980-01-01

Identification of mephenytoin metabolites in the dog.

G Karlaganis, A Küpfer, J Bircher, U P Schlunegger, H Gfeller, P Bigler

Index: Drug Metab. Dispos. 8 , 173, (1980)

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Abstract

In two dogs p-hydroxymephenytoin, m-hydroxymephenytoin, 5-ethyl-5-phenylhydantoin (nirvanol), and 5-ethyl-5-(p-hydroxyphenyl)hydantoin (p-hydroxynirvanol) were identified by use of synthetic metabolites as standards for comparison.