The Journal of organic chemistry

CuI-catalyzed amination of arylhalides with guanidines or amidines: A facile synthesis of 1-H-2-substituted benzimidazoles

X Deng, H McAllister, NS Mani

Index: Deng, Xiaohu; McAllister, Heather; Mani, Neelakandha S. Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5742 - 5745

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Citation Number: 77

Abstract

CuI/L5 (N, N′-dimethylethylenediamine) proves to be an efficient catalyst system for the amination of arylhalides with guanidines. The same catalyst system is then successfully applied to the one-step synthesis of 1-H-2-amino-benzimidazoles through tandem aminations of 1, 2-dihaloarenes in modest yields. This methodology is also applicable for the preparation of 1-H or 1-substutituted 2-aryl-or 2-alkyl-benzimidazoles.

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