Synthetic analogs of daidzein, having more potent osteoblast stimulating effect
…, M Sahai, D Singh, N Chattopadhyay, R Maurya
Index: Yadav, Dinesh K.; Gautam, Abnish K.; Kureel, Jyoti; Srivastava, Kamini; Sahai, Mahendra; Singh, Divya; Chattopadhyay, Naibedya; Maurya, Rakesh Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 677 - 681
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Citation Number: 17
Abstract
A series of didzein derivatives were synthesized and assessed for stimulation of osteoblast differentiation using primary cultures of rat calvarial osteoblasts. Data suggested that three synthetic analogs, 1c, 3a and 3c were several folds more potent than daidzein in stimulating differentiation and mineralization of osteoblasts. Further, these three compounds did not show any estrogen agonistic activity, however had mild estrogen antagonistic effect. Out of ...
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