Anti-diabetic activities of fucosterol from Pelvetia siliquosa.

Yeon Sil Lee, Kuk Hyun Shin, Bak-Kwang Kim, Sanghyun Lee

Index: Arch. Pharm. Res. 27(11) , 1120-2, (2004)

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Abstract

Fucosterol isolated from Pelvetia siliquosa was tested for its anti-diabetic activity in vivo. Fucosterol, when administered orally at 30 mg/kg in streptozotocin-induced diabetic rats, was caused a significant decrease in serum glucose concentrations, and exhibited an inhibition of sorbitol accumulations in the lenses. Fucosterol, when administered orally at 300 mg/kg in epinephrine-induced diabetic rats, was also caused an inhibition of blood glucose level and glycogen degradation. These results demonstrated that fucosterol is a main anti-diabetic principle from the marine algae P. siliquosa.