Tetrahedron

Fused pyrazino [2, 3-b] indolizine and indolizino [2, 3-b] quinoxaline derivatives; synthesis, structures, and properties

…, SM Derwent-Smith, F Issa, JC Morris, LM Rendina…

Index: Bloch, Witold M.; Derwent-Smith, Stephanie M.; Issa, Fatiah; Morris, Jonathan C.; Rendina, Louis M.; Sumby, Christopher J. Tetrahedron, 2011 , vol. 67, # 48 p. 9368 - 9375

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Citation Number: 10

Abstract

The synthesis of six new compounds incorporating either a pyrazino [2, 3-b] indolizine or indolizino [2, 3-b] quinoxaline core are reported in good yield (58–87%). The intermediates for the key cyclization reaction for one set of compounds (5a–c), with a sterically demanding 3, 5-dimethylpyrazole group in the 5-position of the core, were found to be mono-substituted. These intermediates could be isolated and cyclized by heating under acid-catalyzed ...