Biocompatible hydrodispersible magnetite nanoparticles used as antibiotic drug carriers.

Alexandra Bolocan, Dan Eduard Mihaiescu, Ecaterina Andronescu, Georgeta Voicu, Alexandru Mihai Grumezescu, Anton Ficai, Bogdan Ştefan Vasile, Coralia Bleotu, Mariana Carmen Chifiriuc, Corina Silvia Pop

Index: Rom. J. Morphol. Embryol. 56 , 365-70, (2015)

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Abstract

Here we report a newly synthesized vectorizing nanosystem, based on hydrodispersible magnetite nanoparticles (HMNPs) with an average size less than 10 nm, obtained by precipitation of Fe(II) and Fe(III) in basic solution of p-aminobenzoic acid (PABA), characterized by high-resolution transmission electron microscopy (HR-TEM), dynamic light scattering (DLS), X-ray diffraction (XRD), differential thermal analysis coupled with thermogravimetric analysis (DTA-TGA) and bioevaluated for cytotoxicity and antibiotic delivery in active forms. The obtained data demonstrate that HMNPs can be used as an efficient drug delivery system, for clinically relevant antimicrobial drugs. HMNPs antimicrobial activity depended on the loaded drug structure and the tested microbial strain, being more efficient against Pseudomonas aeruginosa, comparing with the Escherichia coli strain. The novel HMNPs demonstrated an acceptable biocompatibility level, being thus a very good candidate for biomedical applications, such as drug delivery or targeting.